Top Central & South America Sightseeing Tours in 2026

Sao Paulo is a sprawling city that can seem daunting to explore. Travelers with a lot of curiosity but not much time will appreciate the chance to maximize sightseeing with more than 20 Sao Paulo sights in one efficient full-day city tour. Before the day is done, you'll see and learn about popular destinations and insider favorites including landmark architecture, bustling neighborhoods, top shopping, emblematic food and drink, museums, street art, churches, and much more.

Unfamiliar areas can be daunting to tackle alone, but this walking tour offers an insider’s perspective on one of Medellin’s most historically and culturally rich neighborhoods, Comuna 13. Explore with confidence as your guide shows you street art you'd struggle to find on your own, and sample local foods, including empanadas and mango ice cream. Finish by riding escalators to a mountain-top viewpoint to admire views across the whole city.

This Humantay Lake Full-Day Tour from Cusco is a great pick for travelers who want to see the lake but only have a day to spare. This full-day tour takes you to the lake through the Soraypampa Trek, which is a circular route that runs about 2.7 miles (4.3 kilometers). A guide knows the best spots to stop at to see wildlife and teaches you about the scared mountains surrounding the area, too.

Experience two of Ushuaia's top attractions on one convenient tour that saves you the hassle of making separate bookings. Pay full attention to the natural wonders of Tierra del Fuego National Park as you're driven between highlights, and ride a historic railway route on the End of the World Train—tickets are included to guarantee your spot on this popular train.

Discover the world-renowned Panama Canal and see the highlights of Panama City at your own pace on this hop-on hop-off city sightseeing tour. Travel in an open-top bus for unobstructed views and disembark at any of the stops when something captures your interest. See the Miraflores locks, Parque Urraca, the Biomuseo, Casco Antiguo, and so much more.

Experience an unforgettable day trip from Lima to Paracas and Huacachina, featuring a guided boat tour of the Ballestas Islands to see sea lions, penguins, and more in their natural habitat. Explore the stunning Huacachina Desert Oasis at your own pace, capped off with a breathtaking desert sunset. Travel in comfort with air-conditioned buses and bilingual guides, with optional local cuisine like ceviche and pisco sours to complete your journey.

Active, outdoor-loving travelers will enjoy the chance to hike to the top of a volcano without getting lost. The logistics will be taken care of so all you have to do is hike. The ascent of Ilamatepec takes about two hours, and the descent another two. Be amazed by the views at the top, including of the green crater lagoon. Relax over a leisurely lunch at Lake Coatepeque.

Get off the beaten path and explore down back roads that aren’t accessible any other way, on this guided ATV tour of Tamarindo. Adult travelers can drive themselves while families with kids can pair up on double ATVs or buggies. Enjoy the views as you drive through forests and rivers to secluded beaches and viewpoints.

On this 3-day/2-night expedition you will get to know this magical Uyuni salt flat, the largest in the world with a route of more than 200 km long and 80 km wide, with more than 64 billion tons of salt, more than 21 million tons of lithium. Of astonishing natural beauty, an amazing island of giant cacti in the middle of the salt flat, a giant mirror in the rainy season , from an impressive sunset, volcanoes in the western mountain range such as the Licancabur, Ollague, Tunupa and other volcanoes, where can practice trekking from 3600 meters high to 5000 meters high, enjoy their hot springs in different places, Laguna Polques hot springs, Laguna Blanca hot springs, etc., inhospitable deserts such as the Siloli desert, Salvador Dalí desert, and observe the fauna and flora of the south west of Potosí, come to know and enjoy a great unforgettable adventure with Andes Salt Expedition with 8 consecutive Awards of Quality Excellence Certifications of service by TRIPADVISOR 2015-2023. ​ ​

Get a more intimate glimpse of the colorful, colonial streets of Cartagena than you would if traveling by coach or car during a private walking tour. Exploring with a private guide allows you to customize your experience according to your interests, as well as receive tailored recommendations to enhance the rest of your vacation. Plus, you guide collects you from your accommodation so you don’t have to worry about finding a meeting point.

Get to know Buenos Aires on this guided half day tour where you'll be driven to several stops in a private, air-conditioned vehicle, and also be walking between places. This is the perfect way to get an overview of the city upon arrival, or for those who have just a few hours in the city to walk. Among the stops are Alberto J. Armando Stadium (La Bombonera), Casa Rosada, and Recoleta Cemetery, but the entrance fees are extra.

Escape the groups and crowds of larger tours on a private half-day city tour of Cartagena. Get an overview of the city and check off its major sights, including its historic center, Castillo San Felipe, and Convento de la Popa. Hear cultural insights from your guide that you might otherwise miss along the way.

Even though Rainbow Mountain isn't close to Cusco, it's still possible to visit in just one day on this guided tour. The day trip takes you to the spectacular summit of Rainbow Mountain with a guide leading the way so you don't get lost. Enhance the challenging trek with commentary and insights from your guide.

Pacaya Volcano is one of the most active—and most popular—in all of Guatemala. Stationed some 8,000 feet (2,500 meters) above sea level, this destination is an ideal spot for travelers who want an easy hike, epic views, and some memorable stories. This tour allows you the comfort and ease of pre-arranged transportation to ensure you get the most out of your hike.

Break less of a sweat than you would on traditional El Chaltén hiking tours on a gentle trekking day trip that’s ideal for less-experienced walkers. You’ll embark on two low-exertion walks that still reveal spectacular views of the landscapes, at a relaxed pace that’s tailored to the whole group.

Discover one of Bolivia’s most extraordinary natural treasures—and enjoy a seamless sightseeing experience—on this full-day, small-group tour of the Uyuni Salt Flat. Traveling in a comfortable and convenient 4x4 vehicle, you’ll immerse yourself in the scenery, spot local wildlife, and learn all about the local salt-producing process. Then, admire the world’s largest salt flat—and have the particularly special chance to see the sun set over the scenery.

The excursion begins when we pick you up in our minibus with your driver and a professional tour guide, to go to Tierra del Fuego National Park. On the End of the World Train, we are going to relive history in time and space. We will travel the same path that many years ago the prisoners traveled. Already in the Tierra del Fuego National Park, you will observe the most characteristic species of the Fuegian forests in a spectacular area of 63,000 hectares. The first point to visit in the park is the End of Route 3, in Lapataia Bay, where we find the famous End of the World sign, which symbolizes the union of Ushuaia and Alaska. Here you will have the most iconic photo that everyone wants to have: The End of the World poster, the End of Route 3 The next stop is at Lake Roca, where we will contemplate a typical Patagonian postcard To finish we will visit the Ensenada Zarategui where the last postal box of Correo Argentino is located.

Experience Belize City through its local flavors on a small-group food tour led by a knowledgeable guide. Sample traditional Belizean snacks and seasonal fruits, visit a rum factory and rum museum for tastings, then finish with a hot tamale lunch in a local park. It’s a flavorful introduction to Belizean culture beyond the city's main sights.

See Antigua from above on this half-day mountain adventure. You’ll visit three scenic mountaintops for panoramic views of the colonial city, lush valleys, and nearby volcanoes. From El Cerro de la Cruz—Antigua’s most famous lookout point—to Hobbitenango, a Lord of the Rings–themed eco-park, you’ll explore a whimsical forest, play games, and scenic viewpoints before catching the sunset over the mountains. On the way back down, there’s an optional stop for food and drinks at a local restaurant on the side of the mountain.

Featuring a chocolate and rum tasting, as well as the opportunity to see monkeys and sloths up close, this private Roatan tour is the perfect way to spend a few hours in Honduras. You'll be picked up in an air-conditioned vehicle from your hotel and taken to Coxen Hole, where you'll see these animals in their natural habitat, visit the island's best viewpoints, and more.

See Buenos Aires on your own terms, at your own pace, by booking hop-on hop-off bus tickets. Passes valid for 24, 48, or 72 hours are available and entitle visitors to get on and off at more than 20 different stops. Once onboard, you can take in views from an open-air deck or stay cool by opting for a seat in the air-conditioned interior, and listen to commentary from a multi-lingual audio guide.

This tour of Roatan Island in Honduras is designed for travelers who want to customize the experience to include just their personal top-priority destinations and activities. Visit the Butterfly Gardens, Gumbalimba Monkey Park, Iguana Farm, or Carambola Botanical Garden. Tour Mahogany Bay, French Harbor, West End, or West Bay plus relax on Tabyana Beach. It's up to you.

Discover the Lake Atitlan area on this half-day ATV adventure. First, head to San Antonio Palopo via the road that runs around the lake. There, visit a local ceramic factory to learn about the production process and also stop by a chocolate factory. Following that, travel to the village of Santa Catarina Palopo where you'll be able to learn about and see the weaving of blankets, and other goods. Lastly, head to Playa Blanca en Barrio Jucanya for some photo opps by the water.