Top Panama City Multi-day Cruises

For travelers who have more than just a day to explore and want to get the most out of their time on the San Blas Islands, this San Blas Islands 3-Day All-Inclusive Sailboat Experience is a great choice. This experience allows you to go to remote areas away from crowds which wouldn’t be possible except by sailboat. Plus, you can snorkel some of the best coral reefs in the world.

Get up close to Panama’s wealth of wildlife on this boat tour of Lake Gatun. Spot monkeys—such as howlers, white-faced capuchins, and tamarins—in their natural habitat, and look out for sloths, anteaters, crocodiles, capybaras, manatees, and a variety of exotic birds. Cruise through this immersive setting with a guide, and benefit from included hotel pickup and drop-off, too.

Discover the wonders of the Panama Canal and learn about its operation on this private tour. Delve into the fascinating history and operations of this engineering marvel at the Miraflores Visitor Center. Then, venture to Gatun Lake for a boat tour, where you'll witness ships navigating the canal's locks and encounter diverse wildlife amidst the lush rainforest of Soberania National Park.

Unique experience to sail in a Private Catamaran in San Blas Islands, Swim and make snorkeling in the best spots, taste delicious food prepared by experts in seafood (Lobster during season), and sleep in your own Private Suite with complete bathroom, hot water, etc. This is the nicest way to meet the region and stay confortable.

Many travelers visit the locks at the Panama Canal but fewer venture to the surrounding islands to explore the biodiversity. On this half-day small-group tour, take a boat ride inside the Panama Canal, looking out for wildlife such as monkeys, iguanas, and sloths. Travel with a small group for personalized attention, and a guide who can answer all your questions. The tour includes admission fees and air-conditioned transfers for added comfort.

Take a break from Panama City and head to the Caribbean coast of Panama, to the beautiful San Blas Islands. Traveling by boat, check out a shipwreck and natural swimming pool, and enjoy the tropical scenery and atmosphere. Your tour includes activities—kayaking, paddle boarding, snorkeling, and more—and round-trip road and boat transport, with hotel pickup and drop-off. Refuel with a tasty included lunch, too, such as fresh fish and rice.

Enjoy a guided sightseeing excursion in Panama’s vibrant capital city. After a convenient hotel pickup, experience one of the world’s great engineering marvels, the Panama Canal, at Miraflores Visitor Center. Take a walking tour of the city’s historic district, Casco Viejo, marvel at the Bridge of the Americas, and stop by the handicraft market at Amador Causeway to pick up some souvenirs.

The San Blas Islands are one of the most beautiful destinations in Panama and home to the Guna Yala people, the largest indigenous group in the country. On this 1- or 2-night tour, Aguja Island is the base for area explorations including a tour of Pelican Island where parts of the Netflix series "Money Heist" were filmed. Enjoy snorkeling, kayaking, and swimming in calm warm water, and relax on a white sand beach.

Escape Panama City on the newest and largest catamaran for a day of boating, swimming and dancing. During this 6-hour tour, you will swim on a beautiful virgin bay, visit the beach and the Island Village. Onboard the catamaran, enjoy sundecks, shaded areas, music, animation, morning snacks, lunch, and an open bar. This 6-hour tour is the perfect choice to avoid the afternoon tropical weather and have enough time for night plans.

If you’re a first-time visitor to Panama City, you’ll want to see the must-visit highlights. This five-hour Private or Share group tour, takes you to the atmospheric old town, the engineering marvel of the Panama Canal, and the sweeping Amador Causeway, with its great views of the city. If you’re short on time or on a quick shore excursion, this convenient tour makes the most of your time.

Discover Panama City on two wheels during this bike tour. Follow your guide around the history-rich Casco Viejo Old Town on this highlights tour that helps you get your bearings in Panama’s capital. Listen to local stories and get recommendations on where to eat and shop along the way. Perfect for guests who want to get an overview of Panama City, with the opportunity to take plenty of pictures along the way.

Cruise the Panama Canal to Gatun Lake on a nature tour from Panama City that includes round-trip transport from central Panama City and time to explore Gatun’s wildlife-rich shoreline by boat. Visit jungle islands that were cut off from mainland Panama by the construction of the canal, which protect a thriving population of monkeys, birds, crocodiles, and mammals.

Cruise the entirety of the Panamá Canal, from the Pacific to the Atlantic Ocean, during this full-day tour in Panamá City. Board a small vessel to travel through all three sets of locks that make up the canal. Voyage on Gatun Lake and the Chagres River. Learn about the history and construction of the canal from your guide while you travel. Disembark in Colón and board a shuttle for the return trip to Panamá City. Breakfast, lunch, snacks and beverages are provided on board. Please Note: The exact check-in time will be confirmed the day before your tour via email. Please make sure you check your inbox.

Travel between the Atlantic and Pacific Oceans during this full-day tour of the Panama Canal. With your local guide, explore the canal by sea and on foot, viewing the ships passing through the locks and the variety of plant and animal life on the canal's shores. Explore Gatun Lake, home to howlers, capuchins, tamarins, and many more animals. Stop at the Agua Clara Locks Visitor Center to get an overview of the canal's history through informative displays and exhibits. Explore San Lorenzo National Park and Fort San Lorenzo, a UNESCO World Heritage Site, and enjoy a picnic lunch. All activities, entrance fees, lunch, and round-trip transportation from Panama City hotels are included.

Discover Panama City by Night – A Captivating Evening Tour This isn’t just a city drive — it’s a carefully curated experience that reveals the magic of Panama City after dark. Enjoy panoramic viewpoints with breathtaking skyline views and photo stops, then take a guided walk through the charming Old Quarter (Casco Antiguo). Wander along cobblestone streets lined with colorful colonial buildings, explore historic plazas like Plaza de Francia and Plaza Bolívar, and admire centuries-old churches such as the Metropolitan Cathedral and San José with its famous Golden Altar. Feel the city’s vibrant spirit as cafés, rooftops, and bars come alive with music and culture. Along the way, stop at iconic sites like the Cinta Costera and Amador Causeway for stunning night views. With friendly bilingual guides, comfortable transportation, and small groups or private service, this tour blends history, culture, and panoramic beauty into one unforgettable evening in Latin America’s most dynamic capital.

Don’t pass up the opportunity to visit the Panama Canal during your layover at Tocumen International Airport. This half-day tour with a private guide provides you with flexibility to explore the sights at your own pace. Stroll past Spanish-colonial architecture on the narrow streets of Casco Antiguo (Old Quarter) and also see the modern side of the city.

"Panama: The Engineering of Destiny" A technical and historical tour of the world axis. Many visit the Channel to watch boats pass by. We come to understand how the world moved. This is not a scenic excursion; it is an immersion in the logistics, resilience and vision that allowed this isthmus to change the global geography. This is not a sightseeing tour; it is a private dive into the backbone of America. Reserved for those who demand exclusivity, our experience connects the colonial legacy of the Old Town with the engineering that defied fate.