Ribboning from the Swiss mountains to the North Sea, the Rhine River is one of Europe’s mightiest waterways. While it passes through six countries in total, the river is best associated with views of the Upper Middle Rhine Valley, a UNESCO World Heritage Site in Germany where vineyards, fairy-tale villages, and medieval castles abound. Writers, artists, and tourists flock to see the scenery that’s spawned so many things to do in the Rhine River region. Those options range from wine tastings and Lorelei Rock cruises to city tours of Cologne and Dusseldorf in North Rhine-Westphalia.