Top Central & South America Multi-day Cruises

The San Blas Islands are one of the most beautiful destinations in Panama and home to the Guna Yala people, the largest indigenous group in the country. On this 1- or 2-night tour, Aguja Island is the base for area explorations including a tour of Pelican Island where parts of the Netflix series "Money Heist" were filmed. Enjoy snorkeling, kayaking, and swimming in calm warm water, and relax on a white sand beach.

We will take you one step beyond in terms of service, intimacy, and personal attention. This classic river cruise features 4 oversized suites, all with private panoramic terraces, 2 of which offer a private whirlpool for the ultimate treat. Floor-to-ceiling windows allow nature to be part of the natural suite décor, and cabin service 3 times a day will ensure you the most personalized experience. On the top deck, guests will find a lounge area, bar, and entertainment center which are perfect places to relax while the jungle unfolds before your eyes.

Discover the sandy beaches and traditional villages of the San Blas Islands along Panama’s Caribbean coast. This island-hopping tour allows you to visit seven different islands in just four days and spend three nights on three different islands. Enjoy boat cruises between the islands, take part in fun activities including swimming, snorkeling, and kayaking, and meet the local Guna Ayala people.

For travelers who have more than just a day to explore and want to get the most out of their time on the San Blas Islands, this San Blas Islands 3-Day All-Inclusive Sailboat Experience is a great choice. This experience allows you to go to remote areas away from crowds which wouldn’t be possible except by sailboat. Plus, you can snorkel some of the best coral reefs in the world.

Explore Chile and North Patagonia on this five day group tour, starting in Puerto Montt. Your driver will be there to take you to Puerto Varas, where you can rest and explore. The following days you’ll visit lakes, monuments, port villages, volcanos, craft stores, islands, and some beautiful beaches and coastline. Your guides and team will take care of all the logistics, so you just need to enjoy the tour.

Unique experience to sail in a Private Catamaran in San Blas Islands, Swim and make snorkeling in the best spots, taste delicious food prepared by experts in seafood (Lobster during season), and sleep in your own Private Suite with complete bathroom, hot water, etc. This is the nicest way to meet the region and stay confortable.

Four days and three nights exploring the wonderful Amazon, the Marañón and Ucayali rivers and their tributaries. The Pacaya Samiria Reserve will be the perfect scenario for a trip into the most exotic areas nature has to offer. As we enter the world’s largest flooded forest, we will admire the extraordinary wildlife, the immense number of primate species, the hundreds of colorful exotic birds, the close-up view of the gray and pink dolphins, visit to local villages, nocturnal wildlife safaris, visit to the Manatee Rescue Center and many additional activities that will allow you to get to know and fall in love with the incredible Amazon.

Experience the Magic of the Amazon Aboard La Perla Set off on an unforgettable 4-day expedition into the heart of the Peruvian Amazon, sailing the mighty Ucayali and Marañón Rivers aboard the charming La Perla cruise ship. This journey offers the perfect balance of comfort, adventure, and cultural immersion, bringing you closer to one of the most biodiverse places on Earth. Explore the wonders of Pacaya Samiria National Reserve, spotting pink river dolphins, monkeys, sloths, and exotic birds on guided boat excursions at sunrise and sunset. Led by expert naturalist guides, you’ll learn about the delicate ecosystem of the rainforest and visit welcoming local communities to connect with their traditions and way of life. Onboard, enjoy delicious regional cuisine, air-conditioned cabins, and panoramic lounges where you can relax and take in the breathtaking views. Book your journey now and cruise deep into the Amazon with La Perla—an experience that will stay with you forever.

We’re delighted to have you on board for this journey of discovery to some of the most beautiful islands in the Galapagos. This itinerary will take us to the true origins of the archipelago, to a world only recently created by the titanic tectonic upheavals of our Earth’s crust, whose volcanic hot spot formed the islands in a blink of an eye in geological time. Fernandina Island is regarded as one of the most pristine island environments anywhere in the world, where life has evolved in its natural state, far from the intervention of man. On Santa Cruz, we visit the Charles Darwin Research Station and get up close to giant tortoises in their natural environment. In the south, we learn about the Galapagos very own “murder mystery”, spot flamingos and snorkel at one of the best sites in the archipelago: Champion Islet. Back in the Central Islands, we head back to Baltra Island for the flight back to the mainland.

Sail through Patagonia's glaciers to the "End of the Earth" on this small-group 5-day cruise from Ushuaia. Save yourself days of arranging logistics with this seamless package, which covers meals, transfers, and accommodation. Travel through Argentina to Chile's Punta Arenas, taking in the scenery in the Beagle Channel and the Strait of Magellan on the way to Cape Horn. Keep watch for penguins, sea lions, and other local wildlife.

Cruise the Galapagos in style aboard a small 20-passenger yacht with a lower impact on the ecosystem. Enjoy Ecuadorian cuisine including cooking and cocktail demonstrations, and learn about Galapagos flora and fauna from your bilingual naturalist guide. Explore Bachas Beach, Tagus Cove, Buccaneer Cove, and more with all meals and 6 nights accommodation included.

For travelers who want to get to the Colombian border from Manaus, all while exploring the Amazon, this 6-day boat trip gets you there. Relax on deck or in your own private cabin during this scenic journey on the Amazon River. Booking is made easier without the hassle of researching cruise operators; three meals per day are included in the price.

Explore both city life and some magnificent nature on this hassle-free group tour that takes you to the highlights from Patagonia to Rio de Janeiro. Accommodation and breakfasts are taken care of, so no need to organize them separately. Each day your guide packs in all sorts of activities-more than you would if you were on an independent trip. One of the top highlights is a trip to Iguazu Falls.

Beginning of the journey to the Meeting of the Waters , where we will observe the Rio Negro and Solimões that together form the Amazon River. Next we will visit the January Lake, where we will see the floating houses located on a inundated area because of the the flood period of the river.

Tour to Torres del Paine from Puerto Natales, where you will know live and direct the wonders of Torres del Paine National Park, a place famous for its granite towers that are located in a place surrounded by multicolored lagoons, large waterfalls, glaciers, forests Patagonian and its incredible flora and fauna that decorate the place, a unique Park in the world and that you can enjoy in the front row on this day trip, for something it was named 2013 as the 8th wonder of the world, you will also have the privilege of Get to know the imposing Milodon Cave, where you will know the history of this place and you will find the replica of the mythical animal, the Milodon, which lived thousands of years ago in this region of Patagonia. Enjoy the Perito Moreno Glacier in the front row. With this to the Glacier Tour to the Perito Moreno will leave you amazed with the ice giant and the landscape that accompanies it. It is a trip that you can enjoy in the front row.

We are offering you an incredible 14 day trip to know the best of Argentina and Chile in an original way. Our trip starts in Santiago de Chile, where you will get to know this sophisticated metropolis surrounded by mountains. From here we continue to the Chilean Patagonia, and then cross the Andes Mountains through several lakes. We will arrive in the Argentinean city of Bariloche, famous ski resort worldwide. We will continue to Buenos Aires, the city that never sleeps. Here you will discover why it is called "the Paris of Latin America". Finally we will travel to the north of the country to visit the Iguazu Falls, one of the Natural Wonders of the World. This package includes accommodation, transfers and excursions.

The Amatista Cruise provides an unforgettable journey through the heart of the Peruvian Amazon, blending comfort, nature, and cultural immersion. Aboard this charming riverboat, guests stay in air-conditioned cabins with large windows offering panoramic views of the rainforest. The experience includes expertly guided boat excursions, jungle walks, and visits to ative communities, providing a deep connection with the Amazon’s unique ecosystem and way of life. Guests can also enjoy delicious local cuisine prepared on board, showcasing the rich flavours of the region. The Amatista is ideal for travellers seeking a genuine and enriching Amazonian adventure

Sail through the glacial waters of Patagonia on this overnight boat tour through the El Calafate region. Get an up-close look at a number of glaciers including Perito Moreno, Upsala, and Spegazzini and disembark the boat for a few short hikes. Enjoy a relaxing journey on Spirit of the Glaciers as well as gourmet cuisine during your tour.

Wake up every morning in front of the majestic Amazon River, listen to birdsong and feel the cool jungle breeze. At Amazon View Hostel, located in the picturesque Pueblo Barrio Florido, every day is a unique experience that combines adventure, culture and rest. Observe one of the most beautiful sunrises in the world, see piranhas, monkeys, pink dolphins, navigate the majestic Amazon river, observe the giant lupun tree, have a spectacular panoramic view from our private viewpoint, walk through the jungle at night, explore the Amazon flora and fauna day and night, we are a local family that welcomes you with a happy heart to make you live unforgettable days with delicious food, we are characterized by offering you a family treatment and make you feel at home. Choose our experience and be part of responsible and safe tourism.

You absolutely will not find another tour out there as packed with activities and attractions as this one, provided by CharlieTheTraveler. You will also not find another tour out there that offers it all "FIRST CLASS," yet for a relatively low price. We focus on small-group experiences, immersive cultural encounters, and seamless logistics, ensuring every journey is personal, enriching, and unforgettable from start to finish. ►A Helicopter Ride Over & Boat Ride to the Continent’s Grandest Waterfalls ►Doorless Helicopter Ride Over Rio de Janeiro (optional add-on) ►Exploring Both the Brazilian & Argentinean Side of Iguazu Falls ►Sightseeing in Rio de Janeiro ►A Wetland Cruise & Exotic Creatures (optional add-on) ►A Daytrip to Brazil’s Most Stylist Beach Resort ►Swimming in the Clearest Rivers on Earth *optional add-on ►An Expedition Around the Country’s Most Popular Island ►Visiting 2 Postcard-Perfect Colonial Towns ►Cruising Along the Tropical Coastline & Snorkeling

On this excursion you will be able to discover 2 of the most important and unmissable tours in Puerto Natales. Tour to Torres del Paine and sailing to the Balmaceda and Serrano glaciers with lunch

On this excursion you will be able to discover 3 of the most important and unmissable tours in Puerto Natales. Tour to Torres del Paine and sailing to the Balmaceda and Serrano glaciers with lunch. Perito Moreno Glacier in Argentina

Step aboard the Santa Cruz vessel and set out across the shimmering waters of Lake Argentino on a journey few travelers ever witness! Spend the night enveloped in absolute stillness in one of the most remote corners of the world, savoring refined Patagonian cuisine and the quiet rhythm of the ice. Experience the Spirit of the Glaciers as you glide past colossal ice walls and silent fjords, where the landscape reveals its extraordinary scale and beauty. When dawn breaks, awaken to glaciers bathed in the first light: a breathtaking moment that feels almost otherworldly! For over 20 years, Signature DMC has specialized in crafting unforgettable experiences, not just trips. Recognized as one of the best in Argentina and South America, we connect cultures through extraordinary journeys.