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Located on the edge of the Gulf of Mexico in southwest Florida, Naples is a prime kicking off point for exploring the Gulf, the Ten Thousand Islands, and even the Everglades. The best way to get on the water is with catamaran cruises from Naples, which offer a variety of ways to see gorgeous vistas, spot marine wildlife, and live the good life on the water. Choose from among myriad options, including group sails, two-person self-guided catamaran tours, and sightseeing cruises across the Ten Thousand Islands.