Top Patagonia Multi-day Cruises

Step aboard the Santa Cruz vessel and set out across the shimmering waters of Lake Argentino on a journey few travelers ever witness! Spend the night enveloped in absolute stillness in one of the most remote corners of the world, savoring refined Patagonian cuisine and the quiet rhythm of the ice. Experience the Spirit of the Glaciers as you glide past colossal ice walls and silent fjords, where the landscape reveals its extraordinary scale and beauty. When dawn breaks, awaken to glaciers bathed in the first light — a breathtaking moment that feels almost otherworldly! For over 20 years, Signature DMC has specialized in crafting unforgettable experiences, not just trips. Recognized as one of the best in Argentina and South America, we connect cultures through extraordinary journeys.

Exploring Patagonia can be difficult to navigate on your own. Avoid the hassle of renting a car and planning the logistics with this 9-day tour of multinational highlights. From a cruise along the UNESCO-listed Perito Moreno Glacier in Argentina to a trek through Chile’s Torres del Paine National Park, see alpine lakes and meadows, jagged mountain peaks, and ancient glaciers as you travel through some of the most breathtaking scenery in South America. Enjoy a balance of scheduled activities and leisure time to pursue additional hiking or explore the Patagonian towns of El Calafate, El Chalten, and Puerto Natales.